Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations

BACKGROUND: Mutations in HERG and KCNQ1 potassium channels have been associated with Long QT syndrome and atrial fibrillation, and more recently with sudden infant death syndrome and sudden unexplained death. In other proteins, disease-associated amino acid mutations have been analyzed according to...

Descripción completa

Detalles Bibliográficos
Autores principales: Jackson, Heather A, Accili, Eric A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483723/
https://www.ncbi.nlm.nih.gov/pubmed/18590565
http://dx.doi.org/10.1186/1471-2148-8-188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483723/
https://www.ncbi.nlm.nih.gov/pubmed/18590565
http://dx.doi.org/10.1186/1471-2148-8-188

Ejemplares similares