DNA Double Strand Breaks Occur Independent of AID in Hypermutating Ig Genes

Somatic hypermutation (SHM) and class switch recombination (CSR) take place in B cells of the germinal center (GC) and are associated with DNA double-strand breaks (DNA-DSBs). Transcription favors the generation of DNA-DSBs in the V-regions and switch regions of Ig genes. Both SHM and CSR are contro...

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Detalles Bibliográficos
Autores principales: Bross, Linda, Jacobs, Heinz
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2485413/
https://www.ncbi.nlm.nih.gov/pubmed/14768938
http://dx.doi.org/10.1080/10446670310001626571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2485413/
https://www.ncbi.nlm.nih.gov/pubmed/14768938
http://dx.doi.org/10.1080/10446670310001626571

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