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DNA Double Strand Breaks Occur Independent of AID in Hypermutating Ig Genes

Somatic hypermutation (SHM) and class switch recombination (CSR) take place in B cells of the germinal center (GC) and are associated with DNA double-strand breaks (DNA-DSBs). Transcription favors the generation of DNA-DSBs in the V-regions and switch regions of Ig genes. Both SHM and CSR are contro...

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Detalles Bibliográficos
Autores principales:	Bross, Linda, Jacobs, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2003
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2485413/ https://www.ncbi.nlm.nih.gov/pubmed/14768938 http://dx.doi.org/10.1080/10446670310001626571

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