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Synthesis of new triazole-based trifluoromethyl scaffolds

Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus of...

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Detalles Bibliográficos
Autores principales: Martinelli, Michela, Milcent, Thierry, Ongeri, Sandrine, Crousse, Benoit
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486457/
https://www.ncbi.nlm.nih.gov/pubmed/18941482
http://dx.doi.org/10.3762/bjoc.4.19