Synthesis of new triazole-based trifluoromethyl scaffolds

Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus of...

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Autores principales: Martinelli, Michela, Milcent, Thierry, Ongeri, Sandrine, Crousse, Benoit
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2008
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486457/
https://www.ncbi.nlm.nih.gov/pubmed/18941482
http://dx.doi.org/10.3762/bjoc.4.19
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author Martinelli, Michela
Milcent, Thierry
Ongeri, Sandrine
Crousse, Benoit
author_facet Martinelli, Michela
Milcent, Thierry
Ongeri, Sandrine
Crousse, Benoit
author_sort Martinelli, Michela
collection PubMed
description Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds.
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spelling pubmed-24864572008-10-20 Synthesis of new triazole-based trifluoromethyl scaffolds Martinelli, Michela Milcent, Thierry Ongeri, Sandrine Crousse, Benoit Beilstein J Org Chem Preliminary Communication Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds. Beilstein-Institut 2008-05-29 /pmc/articles/PMC2486457/ /pubmed/18941482 http://dx.doi.org/10.3762/bjoc.4.19 Text en Copyright © 2008, Martinelli et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Martinelli, Michela
Milcent, Thierry
Ongeri, Sandrine
Crousse, Benoit
Synthesis of new triazole-based trifluoromethyl scaffolds
title Synthesis of new triazole-based trifluoromethyl scaffolds
title_full Synthesis of new triazole-based trifluoromethyl scaffolds
title_fullStr Synthesis of new triazole-based trifluoromethyl scaffolds
title_full_unstemmed Synthesis of new triazole-based trifluoromethyl scaffolds
title_short Synthesis of new triazole-based trifluoromethyl scaffolds
title_sort synthesis of new triazole-based trifluoromethyl scaffolds
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486457/
https://www.ncbi.nlm.nih.gov/pubmed/18941482
http://dx.doi.org/10.3762/bjoc.4.19
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AT ongerisandrine synthesisofnewtriazolebasedtrifluoromethylscaffolds
AT croussebenoit synthesisofnewtriazolebasedtrifluoromethylscaffolds

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