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Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets
BACKGROUND: Cancer is caused by genetic abnormalities, such as mutations of oncogenes or tumor suppressor genes, which alter downstream signal transduction pathways and protein-protein interactions. Comparisons of the interactions of proteins in cancerous and normal cells can shed light on the mecha...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488323/ https://www.ncbi.nlm.nih.gov/pubmed/18590547 http://dx.doi.org/10.1186/1752-0509-2-56 |