A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR

Today's proteome is the result of innumerous gene duplication, mutagenesis, drift and selection processes. Whereas random mutagenesis introduces predominantly only gradual changes in protein function, a case can be made that an abrupt switch in function caused by single amino acid substitutions...

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Detalles Bibliográficos
Autores principales: Resch, Marcus, Striegl, Harald, Henssler, Eva Maria, Sevvana, Madhumati, Egerer-Sieber, Claudia, Schiltz, Emile, Hillen, Wolfgang, Muller, Yves A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490752/
https://www.ncbi.nlm.nih.gov/pubmed/18587152
http://dx.doi.org/10.1093/nar/gkn400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490752/
https://www.ncbi.nlm.nih.gov/pubmed/18587152
http://dx.doi.org/10.1093/nar/gkn400

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