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A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR
Today's proteome is the result of innumerous gene duplication, mutagenesis, drift and selection processes. Whereas random mutagenesis introduces predominantly only gradual changes in protein function, a case can be made that an abrupt switch in function caused by single amino acid substitutions...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490752/ https://www.ncbi.nlm.nih.gov/pubmed/18587152 http://dx.doi.org/10.1093/nar/gkn400 |