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Linking the functions of unrelated proteins using a novel directed evolution domain insertion method

We have successfully developed a new directed evolution method for generating integral protein fusions comprising of one domain inserted within another. Creating two connections between the insert and accepting parent domain can result in the inter-dependence of the separate protein activities, thus...

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Detalles Bibliográficos
Autores principales: Edwards, Wayne R., Busse, Kathy, Allemann, Rudolf K., Jones, D. Dafydd
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490766/
https://www.ncbi.nlm.nih.gov/pubmed/18559359
http://dx.doi.org/10.1093/nar/gkn363