Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

Chronic exposure to inducers of DNA base oxidation and single and double strand breaks contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage, such tumors often contain epigenetically silenced genes with aberrant promoter region CpG island DNA hypermethylation. We...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Hagan, Heather M., Mohammad, Helai P., Baylin, Stephen B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491723/
https://www.ncbi.nlm.nih.gov/pubmed/18704159
http://dx.doi.org/10.1371/journal.pgen.1000155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491723/
https://www.ncbi.nlm.nih.gov/pubmed/18704159
http://dx.doi.org/10.1371/journal.pgen.1000155

Ejemplares similares