CRPV Genomes with Synonymous Codon Optimizations in the CRPV E7 Gene Show Phenotypic Differences in Growth and Altered Immunity upon E7 Vaccination

Papillomaviruses use rare codons relative to their hosts. Recent studies have demonstrated that synonymous codon changes in viral genes can lead to increased protein production when the codons are matched to those of cells in which the protein is being expressed. We theorized that the immunogenicity...

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Detalles Bibliográficos
Autores principales: Cladel, Nancy M., Hu, Jiafen, Balogh, Karla K., Christensen, Neil D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491898/
https://www.ncbi.nlm.nih.gov/pubmed/18698362
http://dx.doi.org/10.1371/journal.pone.0002947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491898/
https://www.ncbi.nlm.nih.gov/pubmed/18698362
http://dx.doi.org/10.1371/journal.pone.0002947

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