Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population

BACKGROUND: The intron 5 of gene LMBR1 is the cis-acting regulatory module for the sonic hedgehog (SHH) gene. Mutation in this non-coding region is associated with preaxial polydactyly, and may play crucial roles in the evolution of limb and skeletal system. METHODOLOGY/PRINCIPAL FINDINGS: We sequen...

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Detalles Bibliográficos
Autores principales: He, Fang, Wu, Dong-Dong, Kong, Qing-Peng, Zhang, Ya-Ping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492787/
https://www.ncbi.nlm.nih.gov/pubmed/18698406
http://dx.doi.org/10.1371/journal.pone.0002948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492787/
https://www.ncbi.nlm.nih.gov/pubmed/18698406
http://dx.doi.org/10.1371/journal.pone.0002948

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