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Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population
BACKGROUND: The intron 5 of gene LMBR1 is the cis-acting regulatory module for the sonic hedgehog (SHH) gene. Mutation in this non-coding region is associated with preaxial polydactyly, and may play crucial roles in the evolution of limb and skeletal system. METHODOLOGY/PRINCIPAL FINDINGS: We sequen...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492787/ https://www.ncbi.nlm.nih.gov/pubmed/18698406 http://dx.doi.org/10.1371/journal.pone.0002948 |