Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

This study aimed to identify signaling pathways that oppose connective tissue fibrosis in the aortic valve. Using valvular interstitial cells (VICs) isolated from porcine aortic valve leaflets, we show that basic fibroblast growth factor (FGF-2) effectively blocks transforming growth factor-β1 (TGF-...

Descripción completa

Detalles Bibliográficos
Autores principales: Cushing, Melinda C., Mariner, Peter D., Liao, Jo-Tsu, Sims, Evan A., Anseth, Kristi S.
Formato: Texto
Lenguaje:English
Publicado: The Federation of American Societies for Experimental Biology 2008
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493079/
https://www.ncbi.nlm.nih.gov/pubmed/18218921
http://dx.doi.org/10.1096/fj.07-087627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493079/
https://www.ncbi.nlm.nih.gov/pubmed/18218921
http://dx.doi.org/10.1096/fj.07-087627

Ejemplares similares