Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

OBJECTIVE—The implication of innate immunity in type 1 diabetes development has long been proposed. High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was recently recognized to be a potent innate inflammatory mediator when released extracellularly. We sought to test...

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Detalles Bibliográficos
Autores principales: Han, Junyan, Zhong, Jinxin, Wei, Wenzhong, Wang, Ying, Huang, Yafei, Yang, Ping, Purohit, Sharad, Dong, Zheng, Wang, Mong-Heng, She, Jin-Xiong, Gong, Feili, Stern, David M., Wang, Cong-Yi
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494682/
https://www.ncbi.nlm.nih.gov/pubmed/18477810
http://dx.doi.org/10.2337/db07-1499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494682/
https://www.ncbi.nlm.nih.gov/pubmed/18477810
http://dx.doi.org/10.2337/db07-1499

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