Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

OBJECTIVE—Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C; encoded by Pck1) catalyzes the first committed step in gluconeogenesis. Extensive evidence demonstrates a direct correlation between PEPCK-C activity and glycemia control. Therefore, we aimed to evaluate the metabolic impact and their u...

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Detalles Bibliográficos
Autores principales: Gómez-Valadés, Alicia G., Méndez-Lucas, Andrés, Vidal-Alabró, Anna, Blasco, Francese X., Chillon, Miguel, Bartrons, Ramon, Bermúdez, Jordi, Perales, José C.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494684/
https://www.ncbi.nlm.nih.gov/pubmed/18443203
http://dx.doi.org/10.2337/db07-1087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494684/
https://www.ncbi.nlm.nih.gov/pubmed/18443203
http://dx.doi.org/10.2337/db07-1087

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