The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

OBJECTIVE— Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate. Genome-wide association studies f...

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Detalles Bibliográficos
Autores principales: Vaxillaire, Martine, Cavalcanti-Proença, Christine, Dechaume, Aurélie, Tichet, Jean, Marre, Michel, Balkau, Beverley, Froguel, Philippe
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494697/
https://www.ncbi.nlm.nih.gov/pubmed/18556336
http://dx.doi.org/10.2337/db07-1807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494697/
https://www.ncbi.nlm.nih.gov/pubmed/18556336
http://dx.doi.org/10.2337/db07-1807

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