ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo

BACKGROUND: Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1α and STAT3 have been implicated in HCC progression, thus representing interesting t...

Descripción completa

Detalles Bibliográficos
Autores principales: Moser, Christian, Lang, Sven A, Mori, Akira, Hellerbrand, Claus, Schlitt, Hans J, Geissler, Edward K, Fogler, William E, Stoeltzing, Oliver
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496914/
https://www.ncbi.nlm.nih.gov/pubmed/18651980
http://dx.doi.org/10.1186/1471-2407-8-206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496914/
https://www.ncbi.nlm.nih.gov/pubmed/18651980
http://dx.doi.org/10.1186/1471-2407-8-206

Ejemplares similares