Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

BACKGROUND: The 70 kDa ribosomal protein S6 kinase (RPS6KB1), located at 17q23, is amplified and overexpressed in 10–30% of primary breast cancers and breast cancer cell lines. p70S6K is a serine/threonine kinase regulated by PI3K/mTOR pathway, which plays a crucial role in control of cell cycle, gr...

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Detalles Bibliográficos
Autores principales: Heinonen, Henna, Nieminen, Anni, Saarela, Matti, Kallioniemi, Anne, Klefström, Juha, Hautaniemi, Sampsa, Monni, Outi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496917/
https://www.ncbi.nlm.nih.gov/pubmed/18652687
http://dx.doi.org/10.1186/1471-2164-9-348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496917/
https://www.ncbi.nlm.nih.gov/pubmed/18652687
http://dx.doi.org/10.1186/1471-2164-9-348

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