Identifying Determinants of Cullin Binding Specificity Among the Three Functionally Different Drosophila melanogaster Roc Proteins via Domain Swapping

BACKGROUND: Cullin-dependent E3 ubiquitin ligases (CDL) are key regulators of protein destruction that participate in a wide range of cell biological processes. The Roc subunit of CDL contains an evolutionarily conserved RING domain that binds ubiquitin charged E2 and is essential for ubiquitylation...

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Detalles Bibliográficos
Autores principales: Reynolds, Patrick J., Simms, Jeffrey R., Duronio, Robert J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500221/
https://www.ncbi.nlm.nih.gov/pubmed/18698375
http://dx.doi.org/10.1371/journal.pone.0002918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500221/
https://www.ncbi.nlm.nih.gov/pubmed/18698375
http://dx.doi.org/10.1371/journal.pone.0002918

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