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The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition
The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3′ specific exo-ribonucleases involved in the degradation of the mRNA poly(A) tail, and it is also involved in th...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504292/ https://www.ncbi.nlm.nih.gov/pubmed/18641416 http://dx.doi.org/10.1093/nar/gkn458 |