Inhibition of Mg(2+) binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region

Among bacterial topoisomerase I enzymes, a conserved methionine residue is found at the active site next to the nucleophilic tyrosine. Substitution of this methionine residue with arginine in recombinant Yersinia pestis topoisomerase I (YTOP) was the only substitution at this position found to induc...

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Detalles Bibliográficos
Autores principales: Sorokin, Elena P., Cheng, Bokun, Rathi, Siddarth, Aedo, Sandra J., Abrenica, Maria V., Tse-Dinh, Yuk-Ching
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504298/
https://www.ncbi.nlm.nih.gov/pubmed/18653534
http://dx.doi.org/10.1093/nar/gkn460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504298/
https://www.ncbi.nlm.nih.gov/pubmed/18653534
http://dx.doi.org/10.1093/nar/gkn460

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