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Inhibition of Mg(2+) binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region
Among bacterial topoisomerase I enzymes, a conserved methionine residue is found at the active site next to the nucleophilic tyrosine. Substitution of this methionine residue with arginine in recombinant Yersinia pestis topoisomerase I (YTOP) was the only substitution at this position found to induc...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504298/ https://www.ncbi.nlm.nih.gov/pubmed/18653534 http://dx.doi.org/10.1093/nar/gkn460 |