In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine–pyrimidine junctions

Herein, we sought new or improved endoribonucleases based on catalytic DNA molecules known as deoxyribozymes. The current repertoire of RNA-cleaving deoxyribozymes can cleave nearly all of the 16 possible dinucleotide junctions with rates of at least 0.1/min, with the exception of pyrimidine–pyrimid...

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Detalles Bibliográficos
Autores principales: Schlosser, Kenny, Gu, Jimmy, Lam, Jeffrey C. F., Li, Yingfu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504313/
https://www.ncbi.nlm.nih.gov/pubmed/18644842
http://dx.doi.org/10.1093/nar/gkn396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504313/
https://www.ncbi.nlm.nih.gov/pubmed/18644842
http://dx.doi.org/10.1093/nar/gkn396

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