Cargando…

The role of transcriptional activator GATA-1 at human β-globin HS2

GATA-1 is an erythroid activator that binds β-globin gene promoters and DNase I hypersensitive sites (HSs) of the β-globin locus control region (LCR). We investigated the direct role of GATA-1 interaction at the LCR HS2 enhancer by mutating its binding sites within minichromosomes in erythroid cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Youngran, Song, Sang-Hyun, Lee, Jong Joo, Choi, Narae, Kim, Chul Geun, Dean, Ann, Kim, AeRi
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504316/ https://www.ncbi.nlm.nih.gov/pubmed/18586828 http://dx.doi.org/10.1093/nar/gkn368

Ejemplares similares

Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites
por: Kim, AeRi, et al.
Publicado: (2007)

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes
por: Woon Kim, Yea, et al.
Publicado: (2011)

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription
por: Yun, Won Ju, et al.
Publicado: (2014)

Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus
por: Kim, Yea Woon, et al.
Publicado: (2015)

Deletion of transcription factor binding motifs using the CRISPR/spCas9 system in the β-globin LCR
por: Kim, Yea Woon, et al.
Publicado: (2017)

PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific α-globin expression
por: Chul Kang, Ho, et al.
Publicado: (2010)

The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene
por: Miccio, Annarita, et al.
Publicado: (2011)

Transcriptional potential of the γ-globin gene is dependent on the CACCC box in a developmental stage-specific manner
por: Li, Qiliang, et al.
Publicado: (2006)

Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acids
por: Lonkar, Pallavi, et al.
Publicado: (2009)

Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis
por: Peng, Linyuan, et al.
Publicado: (2020)

5′HS5 of the Human β-globin Locus Control Region Is Dispensable for the Formation of the β-globin Active Chromatin Hub
por: Chan, Ping Kei, et al.
Publicado: (2008)

SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy
por: Park, Mi Ae, et al.
Publicado: (2008)

Physiological and Aberrant γ-Globin Transcription During Development
por: Barbarani, Gloria, et al.
Publicado: (2021)

A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis
por: Wang, Fang, et al.
Publicado: (2014)

Hypoxia stabilizes SETDB1 to maintain genome stability
por: Park, Sungryul, et al.
Publicado: (2023)

A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis
por: Zhu, Yong, et al.
Publicado: (2013)

Nucleotide sequence and results of test of adaptive evolution in the α-globin gene of octodontoid rodents
por: Tomasco, I.H., et al.
Publicado: (2017)

Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response
por: Misra, Jagannath, et al.
Publicado: (2013)

Exploring membrane-associated NAC transcription factors in Arabidopsis: implications for membrane biology in genome regulation
por: Kim, Sun-Young, et al.
Publicado: (2007)

A NAC transcription factor and SNI1 cooperatively suppress basal pathogen resistance in Arabidopsis thaliana
por: Kim, Ho Soo, et al.
Publicado: (2012)

3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
por: Himadewi, Pamela, et al.
Publicado: (2021)

ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation
por: Kim, Kyu-Han, et al.
Publicado: (2015)

Mass Spectrometry Reveals α-2-HS-Glycoprotein as a Key Early Extracellular Matrix Protein for Conjunctival Cells
por: Makuloluwa, Aruni K., et al.
Publicado: (2020)

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus
por: Junier, Ivan, et al.
Publicado: (2012)

Phosphorylation of the auxin signaling transcriptional repressor IAA15 by MPKs is required for the suppression of root development under drought stress in Arabidopsis
por: Kim, Sun Ho, et al.
Publicado: (2022)

hGATA1 Under the Control of a μLCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1 ( low ) Mutation in Mice
por: Martelli, Fabrizio, et al.
Publicado: (2021)

Trypanosomes can initiate nuclear export co-transcriptionally
por: Goos, Carina, et al.
Publicado: (2019)

Role of GAC63 in transcriptional activation mediated by β-catenin
por: Chen, Yong-Heng, et al.
Publicado: (2007)

Phosphorylation of the transcriptional repressor MYB15 by mitogen-activated protein kinase 6 is required for freezing tolerance in Arabidopsis
por: Kim, Sun Ho, et al.
Publicado: (2017)

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin
por: Doerfler, Phillip A., et al.
Publicado: (2021)

Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells
por: Kim, Jin-Man, et al.
Publicado: (2015)

EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell
por: Yoon, Ina, et al.
Publicado: (2023)

Characterization of DNA-binding activity of Zα domains from poxviruses and the importance of the β-wing regions in converting B-DNA to Z-DNA
por: Van Quyen, Dong, et al.
Publicado: (2007)

Pathogen-induced binding of the soybean zinc finger homeodomain proteins GmZF-HD1 and GmZF-HD2 to two repeats of ATTA homeodomain binding site in the calmodulin isoform 4 (GmCaM4) promoter
por: Park, Hyeong Cheol, et al.
Publicado: (2007)

Interplay of Fli-I and FLAP1 for regulation of β-catenin dependent transcription
por: Lee, Young-Ho, et al.
Publicado: (2006)

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets
por: Weise, Andreas, et al.
Publicado: (2010)

Mycobacterial transcriptional signals: requirements for recognition by RNA polymerase and optimal transcriptional activity
por: Agarwal, Nisheeth, et al.
Publicado: (2006)

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy
por: Yee, Jeong, et al.
Publicado: (2019)

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain
por: Karia, Dimple, et al.
Publicado: (2020)

CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6
por: Lee, Eunhye, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e6cfbvotdqjiqvab7t5q5nrkee