An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection

Hundreds of genes show aberrant DNA hypermethylation in cancer, yet little is known about the causes of this hypermethylation. We identified RIL as a frequent methylation target in cancer. In search for factors that influence RIL hypermethylation, we found a 12-bp polymorphic sequence around its tra...

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Detalles Bibliográficos
Autores principales: Boumber, Yanis A., Kondo, Yutaka, Chen, Xuqi, Shen, Lanlan, Guo, Yi, Tellez, Carmen, Estécio, Marcos R. H., Ahmed, Saira, Issa, Jean-Pierre J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515197/
https://www.ncbi.nlm.nih.gov/pubmed/18725933
http://dx.doi.org/10.1371/journal.pgen.1000162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515197/
https://www.ncbi.nlm.nih.gov/pubmed/18725933
http://dx.doi.org/10.1371/journal.pgen.1000162

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