Cargando…

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Recent evidence supports a neuroprotective role for Wnt signaling in neurodegenerative disorders such as Alzheimer's Disease (AD). In fact, a relationship between amyloid-β-peptide (Aβ)-induced neurotoxicity and a decrease in the cytoplasmic levels of β-catenin has been observed. Apparently Aβ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inestrosa, Nibaldo C, Toledo, Enrique M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515306/ https://www.ncbi.nlm.nih.gov/pubmed/18652670 http://dx.doi.org/10.1186/1750-1326-3-9

Ejemplares similares

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease
por: Tapia-Rojas, Cheril, et al.
Publicado: (2018)

Menopause and development of Alzheimer’s disease: Roles of neural glucose metabolism and Wnt signaling
por: Villaseca, Paulina, et al.
Publicado: (2022)

WNT signaling in neuronal maturation and synaptogenesis
por: Rosso, Silvana B., et al.
Publicado: (2013)

Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer’s Disease
por: Zolezzi, Juan M., et al.
Publicado: (2017)

How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway
por: Bonansco, Christian, et al.
Publicado: (2022)

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
por: Friedli, María Jesús, et al.
Publicado: (2021)

Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
por: Codocedo, Juan Francisco, et al.
Publicado: (2016)

Wnt signaling in the regulation of adult hippocampal neurogenesis
por: Varela-Nallar, Lorena, et al.
Publicado: (2013)

Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics
por: Silva-Alvarez, Carmen, et al.
Publicado: (2013)

Signaling pathway cross talk in Alzheimer’s disease
por: Godoy, Juan A, et al.
Publicado: (2014)

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease
por: Dinamarca, Margarita C., et al.
Publicado: (2012)

How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario
por: Arrázola, Macarena S., et al.
Publicado: (2015)

Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk
por: Bastías-Candia, Sussy, et al.
Publicado: (2019)

Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons
por: Arrázola, Macarena S., et al.
Publicado: (2017)

On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
por: Rivera, Daniela S., et al.
Publicado: (2016)

Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis
por: Ríos, Juvenal A., et al.
Publicado: (2018)

Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons
por: Cisternas, Pedro, et al.
Publicado: (2016)

Wnt Signaling Pathway Dysregulation in the Aging Brain: Lessons From the Octodon degus
por: Inestrosa, Nibaldo C., et al.
Publicado: (2020)

Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality
por: Del Rio, Rodrigo, et al.
Publicado: (2020)

Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer’s Disease
por: Gherardelli, Camila, et al.
Publicado: (2022)

Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease
por: Montecinos-Oliva, Carla, et al.
Publicado: (2015)

Selective Surface and Intraluminal Localization of Wnt Ligands on Small Extracellular Vesicles Released by HT-22 Hippocampal Neurons
por: Torres, Viviana I., et al.
Publicado: (2021)

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
por: Varela-Nallar, Lorena, et al.
Publicado: (2009)

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
por: Cerpa, Waldo, et al.
Publicado: (2010)

Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
por: Godoy, Juan A., et al.
Publicado: (2021)

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs
por: Zolezzi, Juan M., et al.
Publicado: (2014)

Inflammation context in Alzheimer’s disease, a relationship intricate to define
por: Novoa, Catalina, et al.
Publicado: (2022)

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus
por: Toledo, Camilo, et al.
Publicado: (2019)

Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease
por: Cisternas, Pedro, et al.
Publicado: (2021)

Interactions of AChE with Aβ Aggregates in Alzheimer’s Brain: Therapeutic Relevance of IDN 5706
por: Carvajal, Francisco J., et al.
Publicado: (2011)

Editorial: Molecular mechanisms of Alzheimer’s disease: From top to bottom
por: Mello-Carpes, Pâmela B., et al.
Publicado: (2022)

Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers
por: Codocedo, Juan F., et al.
Publicado: (2015)

Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
por: Tapia-Rojas, Cheril, et al.
Publicado: (2015)

Wnt signaling in synaptogenesis of Alzheimer's disease
por: Zhang, Cheng‐Ting, et al.
Publicado: (2023)

Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: potential mechanism for Alzheimer's disease therapy
por: González, Alexis, et al.
Publicado: (2016)

The Gα (o) Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons
por: Ramírez, Valerie T., et al.
Publicado: (2016)

Metal and complementary molecular bioimaging in Alzheimer's disease
por: Braidy, Nady, et al.
Publicado: (2014)

Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
por: Lazo, Oscar M, et al.
Publicado: (2010)

Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
por: Álvarez-Ferradas, Carla, et al.
Publicado: (2022)

Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons
por: Slater, Paula G., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_fndmkusj8rhmtak923jmihm60p