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TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander
In 2006 the protein TDP-43 was identified as the major ubiquitinated component deposited in the inclusion bodies found in two human neurodegenerative diseases, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The pathogenesis of both disorders is unclear, although they are relate...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515551/ https://www.ncbi.nlm.nih.gov/pubmed/18592312 http://dx.doi.org/10.1007/s00335-008-9117-x |