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TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander

In 2006 the protein TDP-43 was identified as the major ubiquitinated component deposited in the inclusion bodies found in two human neurodegenerative diseases, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The pathogenesis of both disorders is unclear, although they are relate...

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Detalles Bibliográficos
Autores principales: Banks, Gareth T., Kuta, Anna, Isaacs, Adrian M., Fisher, Elizabeth M. C.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515551/
https://www.ncbi.nlm.nih.gov/pubmed/18592312
http://dx.doi.org/10.1007/s00335-008-9117-x