Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease

Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR). Humans with AID mutations develop not only the autosomal recessive form of hyper-IgM syndrome (HIGM2) associated with B cell hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Hase, Koji, Takahashi, Daisuke, Ebisawa, Masashi, Kawano, Sayaka, Itoh, Kikuji, Ohno, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515643/
https://www.ncbi.nlm.nih.gov/pubmed/18716662
http://dx.doi.org/10.1371/journal.pone.0003033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515643/
https://www.ncbi.nlm.nih.gov/pubmed/18716662
http://dx.doi.org/10.1371/journal.pone.0003033

Ejemplares similares