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Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease

Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR). Humans with AID mutations develop not only the autosomal recessive form of hyper-IgM syndrome (HIGM2) associated with B cell hy...

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Detalles Bibliográficos
Autores principales:	Hase, Koji, Takahashi, Daisuke, Ebisawa, Masashi, Kawano, Sayaka, Itoh, Kikuji, Ohno, Hiroshi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515643/ https://www.ncbi.nlm.nih.gov/pubmed/18716662 http://dx.doi.org/10.1371/journal.pone.0003033

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