Cargando…

Modelling neurofibromatosis type 1 tibial dysplasia and its treatment with lovastatin

BACKGROUND: Bowing and/or pseudarthrosis of the tibia is a known severe complication of neurofibromatosis type 1 (NF1). Mice with conditionally inactivated neurofibromin (Nf1) in the developing limbs and cranium (Nf1Prx1) show bowing of the tibia caused by decreased bone mineralisation and increased...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kolanczyk, Mateusz, Kühnisch, Jirko, Kossler, Nadine, Osswald, Monika, Stumpp, Sabine, Thurisch, Boris, Kornak, Uwe, Mundlos, Stefan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516519/ https://www.ncbi.nlm.nih.gov/pubmed/18671844 http://dx.doi.org/10.1186/1741-7015-6-21

Ejemplares similares

MIA is a potential biomarker for tumour load in neurofibromatosis type 1
por: Kolanczyk, Mateusz, et al.
Publicado: (2011)

Multiscale, Converging Defects of Macro-Porosity, Microstructure and Matrix Mineralization Impact Long Bone Fragility in NF1
por: Kühnisch, Jirko, et al.
Publicado: (2014)

Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation
por: Geissler, Sven, et al.
Publicado: (2018)

Double NF1 Inactivation Affects Adrenocortical Function in NF1Prx1 Mice and a Human Patient
por: Kobus, Karolina, et al.
Publicado: (2015)

NOA1 is an essential GTPase required for mitochondrial protein synthesis
por: Kolanczyk, Mateusz, et al.
Publicado: (2011)

A randomized placebo‐controlled lovastatin trial for neurobehavioral function in neurofibromatosis I
por: Bearden, Carrie E., et al.
Publicado: (2016)

Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1
por: Mainberger, Florian, et al.
Publicado: (2013)

Left Ventricular Noncompaction in Children: The Role of Genetics, Morphology, and Function for Outcome
por: Klaassen, Sabine, et al.
Publicado: (2022)

Disease relevance of rare VPS13B missense variants for neurodevelopmental Cohen syndrome
por: Zorn, Malte, et al.
Publicado: (2022)

Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively - coincidence within one family
por: Baasanjav, Sevjidmaa, et al.
Publicado: (2010)

Cortical inhibition in neurofibromatosis type 1 is modulated by lovastatin, as demonstrated by a randomized, triple-blind, placebo-controlled clinical trial
por: Bernardino, Inês, et al.
Publicado: (2022)

Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin
por: Vree, Tom B., et al.
Publicado: (2003)

Structural basis for the biosynthesis of lovastatin
por: Wang, Jialiang, et al.
Publicado: (2021)

RIKADA Study Reveals Risk Factors in Pediatric Primary Cardiomyopathy
por: Al‐Wakeel‐Marquard, Nadya, et al.
Publicado: (2019)

Midwall Fibrosis and Cardiac Mechanics: Rigid Body Rotation Is a Novel Marker of Disease Severity in Pediatric Primary Dilated Cardiomyopathy
por: Al-Wakeel-Marquard, Nadya, et al.
Publicado: (2022)

Effects of lovastatin on breast cancer cells: a proteo-metabonomic study
por: Klawitter, Jelena, et al.
Publicado: (2010)

Microbial Production and Biomedical Applications of Lovastatin
por: Seenivasan, A., et al.
Publicado: (2008)

The role of lovastatin in the attenuation of COVID-19
por: Karampoor, Sajad, et al.
Publicado: (2021)

Effects of Lovastatin on Brain Cancer Cells
por: Amadasu, Efosa, et al.
Publicado: (2022)

Ruptured tibial artery in neurofibromatosis type 1: A case report
por: Matsuura, Sohei, et al.
Publicado: (2021)

Brain Herniation in Neurofibromatosis with Dysplasia of Occipital Bone and Posterior Skull Base
por: Rangarajan, Vithal, et al.
Publicado: (2015)

Lovastatin Protects against Experimental Plague in Mice
por: Ayyadurai, Saravanan, et al.
Publicado: (2010)

Improved bioavailability through floating microspheres of lovastatin
por: Kumar, S., et al.
Publicado: (2011)

Lovastatin‐Mediated Changes in Human Tendon Cells
por: Kuzma‐Kuzniarska, Maria, et al.
Publicado: (2015)

Optimization of lovastatin production from Aspergillus fumigatus
por: Mouafi, Foukia E., et al.
Publicado: (2016)

Nanoparticles of Lovastatin: Design, Optimization and in vivo Evaluation
por: Gaber, Dalia A
Publicado: (2020)

The role of imaging in diagnosing an unusual manifestation of neurofibromatosis type 1: calvarial dysplasia
por: Langer, Felipe Welter, et al.
Publicado: (2018)

Sphenoid Wing Dysplasia in the Absence of Neurofibromatosis: Diagnosis and Management of a Novel Phenotype
por: Zapatero, Zachary D., et al.
Publicado: (2021)

Reconstruction of Sphenoid Wing Dysplasia in Neurofibromatosis Type-1 Patients: An Evolving Technique
por: Goddard, Mr Naveen Virin, et al.
Publicado: (2021)

Management of spinal deformities and tibial pseudarthrosis in children with neurofibromatosis type 1 (NF-1)
por: Mladenov, Kiril V., et al.
Publicado: (2020)

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica
por: Chan, Wing Lee, et al.
Publicado: (2018)

Proposal for Publishing and Parallel Reporting of Case Reports on Adverse Drug Reactions to Authorities by Physicians
por: Sickmüller, Barbara, et al.
Publicado: (2013)

Isolation, Identification, and Characterization of an Unknown Impurity in Lovastatin EP
por: Belwal, Chandrakant, et al.
Publicado: (2014)

Lovastatin Production by Aspergillus sclerotiorum Using Agricultural Waste
por: Iewkittayakorn, Jutarut, et al.
Publicado: (2020)

Lovastatin as a supplement to mitigate rumen methanogenesis: an overview
por: Ábrego-Gacía, Amaury, et al.
Publicado: (2021)

Neonatal osteofibrous dysplasia: Synchronous tibial and fibular involvement is common
por: Laidlow-Singh, Harsimran, et al.
Publicado: (2022)

Correction to: Management of spinal deformities and tibial pseudarthrosis in children with neurofibromatosis type 1 (NF-1)
por: Mladenov, Kiril V., et al.
Publicado: (2021)

GOPHER: Generator Of Probes for capture Hi-C Experiments at high Resolution
por: Hansen, Peter, et al.
Publicado: (2019)

Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease
por: Klawitter, Jelena, et al.
Publicado: (2013)

Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis
por: Chan, David Y. L., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_l4oqaboeqcb8sblb4i0562a3l8