Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

BACKGROUND: Dysregulated PI3K/Akt signaling occurs commonly in breast cancers and is due to HER2 amplification, PI3K mutation or PTEN inactivation. The objective of this study was to determine the role of Akt activation in breast cancer as a function of mechanism of activation and whether inhibition...

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Detalles Bibliográficos
Autores principales: She, Qing-Bai, Chandarlapaty, Sarat, Ye, Qing, Lobo, Jose, Haskell, Kathleen M., Leander, Karen R., DeFeo-Jones, Deborah, Huber, Hans E., Rosen, Neal
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516933/
https://www.ncbi.nlm.nih.gov/pubmed/18725974
http://dx.doi.org/10.1371/journal.pone.0003065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516933/
https://www.ncbi.nlm.nih.gov/pubmed/18725974
http://dx.doi.org/10.1371/journal.pone.0003065

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