Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential

Mild uncoupling of oxidative phosphorylation, caused by a leak of protons back into the matrix, limits mitochondrial production of ROS (reactive oxygen species). This proton leak can be induced by the lipid peroxidation products of ROS, such as HNE (4-hydroxynonenal). HNE activates uncoupling protei...

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Detalles Bibliográficos
Autores principales: Parker, Nadeene, Vidal-Puig, Antonio, Brand, Martin D.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2008
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518262/
https://www.ncbi.nlm.nih.gov/pubmed/18384278
http://dx.doi.org/10.1042/BSR20080002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518262/
https://www.ncbi.nlm.nih.gov/pubmed/18384278
http://dx.doi.org/10.1042/BSR20080002

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