HES-1 Is Involved in Adaptation of Adult Human β-Cells to Proliferation In Vitro

OBJECTIVE—In vitro expansion of β-cells from adult human islets could solve the tissue shortage for cell replacement therapy of diabetes. Culture of human islet cells typically results in <16 cell doublings and loss of insulin expression. Using cell lineage tracing, we demonstrated that the expan...

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Detalles Bibliográficos
Autores principales: Bar, Yael, Russ, Holger A., Knoller, Sarah, Ouziel-Yahalom, Limor, Efrat, Shimon
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518492/
https://www.ncbi.nlm.nih.gov/pubmed/18599525
http://dx.doi.org/10.2337/db07-1323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518492/
https://www.ncbi.nlm.nih.gov/pubmed/18599525
http://dx.doi.org/10.2337/db07-1323

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