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The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic β-cells and is activated by long-chain fatty acids. Gene deletion studies have shown that GPR40 mediates, at least in part, fatty acid–amplification of glucose-induced insulin secretion (GSIS) but is not implicated in GSIS its...

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Detalles Bibliográficos
Autores principales:	Kebede, Melkam, Alquier, Thierry, Latour, Martin G., Semache, Meriem, Tremblay, Caroline, Poitout, Vincent
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518494/ https://www.ncbi.nlm.nih.gov/pubmed/18559658 http://dx.doi.org/10.2337/db08-0553

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