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uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180
The urokinase-type plasminogen activator receptor (uPAR) drives tumor cell membrane protrusion and motility through activation of Rac; however, the pathway leading from uPAR to Rac activation has not been described. In this study we identify DOCK180 as the guanine nucleotide exchange factor acting d...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518715/ https://www.ncbi.nlm.nih.gov/pubmed/18725541 http://dx.doi.org/10.1083/jcb.200712050 |