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Preventing Voltage-dependent Gating of Anthrax Toxin Channels Using Engineered Disulfides
The channel-forming component of anthrax toxin, (PA(63))(7), is a heptameric water-soluble protein at neutral pH, but under acidic conditions it spontaneously inserts into lipid bilayers to form a 14-stranded β-barrel ion-conducting channel. This channel plays a vital role in anthrax pathogenesis be...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518729/ https://www.ncbi.nlm.nih.gov/pubmed/18725530 http://dx.doi.org/10.1085/jgp.200809984 |