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Preventing Voltage-dependent Gating of Anthrax Toxin Channels Using Engineered Disulfides

The channel-forming component of anthrax toxin, (PA(63))(7), is a heptameric water-soluble protein at neutral pH, but under acidic conditions it spontaneously inserts into lipid bilayers to form a 14-stranded β-barrel ion-conducting channel. This channel plays a vital role in anthrax pathogenesis be...

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Detalles Bibliográficos
Autores principales:	Anderson, Damon S., Blaustein, Robert O.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518729/ https://www.ncbi.nlm.nih.gov/pubmed/18725530 http://dx.doi.org/10.1085/jgp.200809984

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