Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

Mechanisms by which hepatitis C virus (HCV) evades cellular immunity to establish persistence in chronically infected individuals are not clear. Mutations in human leukocyte antigen (HLA) class I-restricted epitopes targeted by CD8(+) T cells are associated with persistence, but the extent to which...

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Detalles Bibliográficos
Autores principales: Uebelhoer, Luke, Han, Jin-Hwan, Callendret, Benoit, Mateu, Guaniri, Shoukry, Naglaa H., Hanson, Holly L., Rice, Charles M., Walker, Christopher M., Grakoui, Arash
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518852/
https://www.ncbi.nlm.nih.gov/pubmed/18773115
http://dx.doi.org/10.1371/journal.ppat.1000143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518852/
https://www.ncbi.nlm.nih.gov/pubmed/18773115
http://dx.doi.org/10.1371/journal.ppat.1000143

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