Importance of SARS-CoV spike protein Trp-rich region in viral infectivity

SARS-CoV entry is mediated by spike glycoprotein. During the viral and host cellular membrane fusion, HR1 and HR2 form 6-helix bundle, positioning the fusion peptide closely to the C-terminal region of ectodomain to drive apposition and subsequent membrane fusion. Connecting to the HR2 region is a T...

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Detalles Bibliográficos
Autores principales: Lu, Yanning, Neo, Tuan Ling, Liu, Ding Xiang, Tam, James P.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. Published by Elsevier Inc. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519895/
https://www.ncbi.nlm.nih.gov/pubmed/18424264
http://dx.doi.org/10.1016/j.bbrc.2008.04.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519895/
https://www.ncbi.nlm.nih.gov/pubmed/18424264
http://dx.doi.org/10.1016/j.bbrc.2008.04.044

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