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Importance of SARS-CoV spike protein Trp-rich region in viral infectivity
SARS-CoV entry is mediated by spike glycoprotein. During the viral and host cellular membrane fusion, HR1 and HR2 form 6-helix bundle, positioning the fusion peptide closely to the C-terminal region of ectodomain to drive apposition and subsequent membrane fusion. Connecting to the HR2 region is a T...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc. Published by Elsevier Inc.
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519895/ https://www.ncbi.nlm.nih.gov/pubmed/18424264 http://dx.doi.org/10.1016/j.bbrc.2008.04.044 |