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Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

In mantle cell lymphoma (MCL) and some cases of multiple myeloma (MM), cyclin D1 expression is deregulated by chromosome translocations involving the immunoglobulin heavy chain (IgH) locus. To evaluate the mechanisms responsible, gene targeting was used to study long-distance gene regulation. Remark...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Huang, Jing, Wang, Jin, Jiang, Shuguang, Bailey, Alexis S., Goldman, Devorah C., Welcker, Markus, Bedell, Victoria, Slovak, Marilyn L., Clurman, Bruce, Thayer, Mathew, Fleming, William H., Epner, Elliot
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525596/
https://www.ncbi.nlm.nih.gov/pubmed/18625744
http://dx.doi.org/10.1084/jem.20072102