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Coupled Ion Movement Underlies Rectification in an Inward-Rectifier K(+) Channel

We studied block of the internal pore of the ROMK1 inward-rectifier K(+) channel by Mg(2+) and five quaternary ammoniums (tetramethylammonium, tetraethylammonium, tetrapropylammonium, tetrabutylammonium, and tetrapentylammonium). The apparent affinity of these blockers varied as a function of membra...

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Detalles Bibliográficos
Autores principales: Spassova, Maria, Lu, Zhe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525747/
https://www.ncbi.nlm.nih.gov/pubmed/9689028