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Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways
The yeast URA2 gene, encoding the rate-limiting enzyme of UTP biosynthesis, is transcriptionally activated by UTP shortage. In contrast to other genes of the UTP pathway, this activation is not governed by the Ppr1 activator. Moreover, it is not due to an increased recruitment of RNA polymerase II a...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525842/ https://www.ncbi.nlm.nih.gov/pubmed/18716630 http://dx.doi.org/10.1038/emboj.2008.165 |