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Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival
Mice with a T cell–specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasis and develop fatal colitis. In this study, we show that one critical activity of Blimp-1 in T cells is to repress IL-2, and that it does so by direct repression of Il2 transcription, and also by repressi...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526191/ https://www.ncbi.nlm.nih.gov/pubmed/18725523 http://dx.doi.org/10.1084/jem.20080526 |