T cell–independent development and induction of somatic hypermutation in human IgM(+)IgD(+)CD27(+) B cells

IgM(+)IgD(+)CD27(+) B cells from peripheral blood have been described as circulating marginal zone B cells. It is still unknown when and where these cells develop. These IgM(+)IgD(+)CD27(+) B cells exhibit somatic hypermutations (SHMs) in their B cell receptors, but the exact nature of the signals l...

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Detalles Bibliográficos
Autores principales: Scheeren, Ferenc A., Nagasawa, Maho, Weijer, Kees, Cupedo, Tom, Kirberg, Jörg, Legrand, Nicolas, Spits, Hergen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526198/
https://www.ncbi.nlm.nih.gov/pubmed/18695003
http://dx.doi.org/10.1084/jem.20070447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526198/
https://www.ncbi.nlm.nih.gov/pubmed/18695003
http://dx.doi.org/10.1084/jem.20070447

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