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T cell–independent development and induction of somatic hypermutation in human IgM(+)IgD(+)CD27(+) B cells
IgM(+)IgD(+)CD27(+) B cells from peripheral blood have been described as circulating marginal zone B cells. It is still unknown when and where these cells develop. These IgM(+)IgD(+)CD27(+) B cells exhibit somatic hypermutations (SHMs) in their B cell receptors, but the exact nature of the signals l...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526198/ https://www.ncbi.nlm.nih.gov/pubmed/18695003 http://dx.doi.org/10.1084/jem.20070447 |