Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

Interference with inhibitory immunological checkpoints controlling T cell activation provides new opportunities to augment cancer immunotherapies. Whereas cytotoxic T lymphocyte–associated antigen-4 blockade has shown promising preclinical and clinical results, therapeutic CD4(+)CD25(+) T reg cell d...

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Detalles Bibliográficos
Autores principales: Quezada, Sergio A., Peggs, Karl S., Simpson, Tyler R., Shen, Yuelei, Littman, Dan R., Allison, James P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526206/
https://www.ncbi.nlm.nih.gov/pubmed/18725522
http://dx.doi.org/10.1084/jem.20080099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526206/
https://www.ncbi.nlm.nih.gov/pubmed/18725522
http://dx.doi.org/10.1084/jem.20080099

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