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Many Commercially Available Antibodies for Detection of CHOP Expression as a Marker of Endoplasmic Reticulum Stress Fail Specificity Evaluation

Endoplasmic reticulum (ER) stress contributes to beta cell death in type 2 diabetes (T2DM). ER stress is characterized by increased level of ER stress markers such as C/EBP homologous protein (CHOP). Activation of CHOP leads to its translocation into the nucleus, where it induces cell death. We prev...

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Detalles Bibliográficos
Autores principales: Haataja, Leena, Gurlo, Tatyana, Huang, Chang-jiang, Butler, Peter C.
Formato: Texto
Lenguaje:English
Publicado: Humana Press Inc 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527405/
https://www.ncbi.nlm.nih.gov/pubmed/18651105
http://dx.doi.org/10.1007/s12013-008-9019-2