Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1...

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Autores principales: Seenath, M M, Roberts, D, Cawthorne, C, Saunders, M P, Armstrong, G R, O'Dwyer, S T, Stratford, I J, Dive, C, Renehan, A G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527799/
https://www.ncbi.nlm.nih.gov/pubmed/18648372
http://dx.doi.org/10.1038/sj.bjc.6604474
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author Seenath, M M
Roberts, D
Cawthorne, C
Saunders, M P
Armstrong, G R
O'Dwyer, S T
Stratford, I J
Dive, C
Renehan, A G
author_facet Seenath, M M
Roberts, D
Cawthorne, C
Saunders, M P
Armstrong, G R
O'Dwyer, S T
Stratford, I J
Dive, C
Renehan, A G
author_sort Seenath, M M
collection PubMed
description Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1α nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.
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spelling pubmed-25277992009-09-11 Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer Seenath, M M Roberts, D Cawthorne, C Saunders, M P Armstrong, G R O'Dwyer, S T Stratford, I J Dive, C Renehan, A G Br J Cancer Short Communication Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1α nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain. Nature Publishing Group 2008-08-05 2008-07-22 /pmc/articles/PMC2527799/ /pubmed/18648372 http://dx.doi.org/10.1038/sj.bjc.6604474 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Seenath, M M
Roberts, D
Cawthorne, C
Saunders, M P
Armstrong, G R
O'Dwyer, S T
Stratford, I J
Dive, C
Renehan, A G
Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
title Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
title_full Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
title_fullStr Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
title_full_unstemmed Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
title_short Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
title_sort reciprocal relationship between expression of hypoxia inducible factor 1α (hif-1α) and the pro-apoptotic protein bid in ex vivo colorectal cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527799/
https://www.ncbi.nlm.nih.gov/pubmed/18648372
http://dx.doi.org/10.1038/sj.bjc.6604474
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